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Taken together, these results suggest that -syn undergoes aggregation (the formation of oligomers and fibrils) specifically inside UBQLN2 droplets, and indicate that the liquidgel/solid transition of droplets occurs at concentrations similar to those estimated in vivo (Dao et al, 2018

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While the assessment indicators or methods in animal models, such as Micro-CT, directly simulate the degeneration of bone structure in human osteoporosis, and the Micro-CT indicators are highly correlated with the bone mineral density measured by DXA, also indicating the risk of fractures

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